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Discovery Antibodies/Talipexole dihydrochloride/10 mg/B-140-10 mg,Discovery,,Discovery Antibodies,discoveryantibodies,Discovery,Discovery,+,,Array.Array.Array蚂蚁淘厂家直采.
主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Discovery Antibodies/Talipexole dihydrochloride/10 mg/B-140-10 mg
产品编号:B-140-10mg
市  场 价:¥1740.00
场      地:美国(厂家直采)
产品分类: 抗体类>二抗>抗牛>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$87.00
品      牌: Discovery
公      司:Discovery Antibodies
公司分类:
Discovery Antibodies/Talipexole dihydrochloride/10 mg/B-140-10 mg
商品介绍
Cat#:B-140
AlternativeNameB-HT920
  • LyophilizedPowder
  • BioassayTested
  • SourceSynthetic
    MW:282.23
    Purity:>98%
    Effectiveconcentration0.3-300nM.
      • Talipexole dihydrochloride
    Chemicalname6-prop-2-enyl-4,5,7,8-tetrahydro-[1,3]thiazolo[4,5-d]azepin-2-amine;dihydrochloride.
    MolecularformulaC10H15N3S•2HCl.
    CASNo.:36085-73-1.
    ActivityB-HT920isablockerof5-HT3channels1.ItisalsoanagoNISTofD2dopaminereceptorsandα2-adrenoceptors.
      • Nishio,H. etal. (1996) Gen.Pharmacol. 27, 779.
    ShippingandstorageShippedatroomtemperature.Productassuppliedcanbestoredintactatroomtemperatureforseveralweeks.Forlongerperiods,itshouldbestoredat-20°C.
    Solubility100mMinH2O.Centrifugeallproductpreparationsbeforeuse(10000xg5min).
    StorageofsolutionsUptofourweeksat4°Corthreemonthsat-20°C.
      • Talipexole dihydrochloride
        AlomoneLabs Talipexoledihydrochloride(B-HT920) blocks5-HT3AreceptorsexpressedinHEK293Tcells. 
        Currentswereelicitedby10µM5-HT,deliveredevery3minutes.Talipexoledihydrochloride (#B-140)wasapplied30secondsbeforestimulationat10and100µM,asindicatedandinhibitedthe5-HTinducedcurrentinadose-dependentandreversIBLemanner.
    References-Scientificbackground
    • 1.Nishio,H. etal. (1996) Gen.Pharmacol. 27, 779.
    • 2.Clarke,P.B. etal. (1990) Br.J.Pharmacol. 99, 509.
    • 3.Plosker,G.L.andBenfield,P. (1997) CNSDrugs 7, 410.
    • 4.Inoue,Y. etal. (1999) PsychiatryClin.Neurosci. 53, 283.
      • Talipexoleisanazepinederivative,andactsasanagonistofD2dopaminepre-andpostsynapticreceptors,aswellasan α2-adrenoceptoragonistand5-HT3receptorantagonist1.

        ThepurposeofTalipexoleistoincreasedopamineactivityinthecentralnervoussystem.ItinhibitselectricallyevokedreleaseofdopaminethroughactivationofD2synapticautoreceptorslocatedondopaminergicterminals.Italsocausesreleaseofacetylcholineandnoradrenalin2,3.

        Talipexolehasbeenestablishedinanumberofclinicaltrialsasananti-Parkinsonianagent.Thesetrialsshowedsignificantimprovementinmotoractivityandinotherparkinsoniansymptomsincludingakinesia,rigidity,tremorandgaitdisturbances.Thereareseveralsideeffectscausedbythisdrugsuchasdrowsiness,dizziness,hallucinations,gastrointestinaldiscomfort,nauseaandlossofappetite3.

        Inaddition,talipexoleisalsoexpectedtobebeneficialforthetreatmentofperiodiclegmovementdisorderandrestlesslegsyndrome4.

    Target5-HT3,D2 dopamine,α2-adrenoceptorreceptors
    receivea5mgfreetrialsample!
    Lastupdate:02/09/2019

    Talipexoledihydrochloride(#B-140) isahighlypure,synthetic,andbiologicallyactivecompound.

    Forresearchpurposesonly,notforhumanuse
    品牌介绍

    Discoveryantibodies


    CRB是世界上第二大肽公司,也是抗体研究市场的先驱,它现在正在探索抗体的旗帜下建立一批新验证的目标抗体。


    CRB, the 2nd oldest peptide company in the world and forerunner in the antibody research market is now building a collection of newly validated target antibodies under the banner of Discovery® Antibodies.


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