Deprecated: Required parameter $cat_id follows optional parameter $type in /data/ebiomall/systems/hong.php on line 2088

Deprecated: Required parameter $where follows optional parameter $tree_id in /data/ebiomall/systems/hlb.php on line 3505
Discovery Antibodies/CMPDA/10 mg/C-215-10 mg,Discovery,,Discovery Antibodies,discoveryantibodies,Discovery,Discovery,+,,Array.Array.Array蚂蚁淘厂家直采.
主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Discovery Antibodies/CMPDA/10 mg/C-215-10 mg
产品编号:C-215-10mg
市  场 价:¥1940.00
场      地:美国(厂家直采)
产品分类: 抗体类>二抗>抗荧光素>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$97.00
品      牌: Discovery
公      司:Discovery Antibodies
公司分类:
Discovery Antibodies/CMPDA/10 mg/C-215-10 mg
商品介绍
Cat#:C-215
  • LyophilizedPowder
  • BioassayTested
  • SourceSynthetic
    MW:376.1
    Purity:>99.9%
    FormLyophilizedpowder.
    Effectiveconcentration40nM-10µM.
      • CMPDA
    ChemicalnameN,N"-(1,4-phenylenedi-2,1-ethanediyl­)bis-2-propanesulfonamide.
    MolecularformulaC16H28N2O4S2.
    CASNo.:380607-77-2.
    ActivityCMPDAisaselectiveAMPAreceptoragoNIST(allostericpotentiator).EC50 =45.4and63.4nMatGluR2iandGluR2orespectively,inacalciuminfluxscreeningassay1.
      • Timm,D.E. etal.(2011) Mol.Pharmacol80, 267.
    ShippingandstorageShippedatroomtemperature.Productassuppliedcanbestoredintactatroomtemperatureforseveralweeks.Forlongerperiods,itshouldbestoredat-20°C.
    Solubility100mMinDMSO.Centrifugeallproductpreparationsbeforeuse(10000xgfor1min).
    StorageofsolutionsUptofourweeksat4°Corthreemonthsat-20°C.
      • CMPDA
        AlomoneLabsCMPDApotentiatesGluA1channelsexpressedin Xenopus oocytes.
        TimecourseofcurrentreversIBLepotentiationby100nM CMPDA (#C-215)ofglutamate-elicitedcurrents(100μM,holdingpotential-80mV).
    References-Scientificbackground
    • 1.Suppiramaniam,V. etal.(2001) Synapse 40, 154.
    • 2.Timm,D.E. etal.(2011) Mol.Pharmacol80, 267.
      • CMPDAisanovelpositiveallostericmodulatorofAMPAreceptors.SuchallostericmodulatorsactbyenhancingnormalAMPAreceptoractivitytomimiclong-termpotentiationandprolongopen-channeltimebyslowingorpreventingchannelclosure.Slowingtheterminationofaglutamate-evokedresponseenhancesexcitatorypostsynapticpotentialsbyincreasingionfluxthroughAMPAreceptorchannels1.CMPDAmodulatesAMPAsubunitGluA2receptor(GluR2)anditsdesensitizationanddeactivation(EC50 =45.4and63.4nMatGluR2iandGluR2orespectively,inacalciuminfluxscreeningassayofGluA2iandGluA2oreceptorsexpressedinHEK293cells).Thiscompoundbindsatthemodulatorbindingpocketlocatedattheinterdimerinterfaceandtheclamshellhinges2.ThispocketisapowerfultargetfordrugdiscoveryofcompoundsthatmodulateAMPAreceptorsandisapossiblesiteofactionforendogenousmetabolites.
    TargetAMPAreceptors
    receivea5mgfreetrialsample!
    Lastupdate:24/09/2019

    CMPDA(#C-215) isahighlypure,synthetic,andbiologicallyactivecompound.

    Forresearchpurposesonly,notforhumanuse
    品牌介绍

    Discoveryantibodies


    CRB是世界上第二大肽公司,也是抗体研究市场的先驱,它现在正在探索抗体的旗帜下建立一批新验证的目标抗体。


    CRB, the 2nd oldest peptide company in the world and forerunner in the antibody research market is now building a collection of newly validated target antibodies under the banner of Discovery® Antibodies.


    品牌

    货号

    名称

    规格

    Discoveryantibodies

    crb2005253

    Anti-crc antibody

     20ul 100ul

    Discoveryantibodies

    crb2005041

    Anti-IL-11 antibody

    20ug 100ug

    Discoveryantibodies

    crb2005038

    Anti-RAMP1 antibody

    20ug 100ug


    自营商城图标
    厂家直采
    全球直采 正品优价
    正品保障图标
    正品保障
    厂家直发 有线跟踪
    解放采购图标
    正规清关
    CIF100%正规报关,提供发票
    及时交付图标
    及时交付
    限时必达 不达必赔