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Discovery Antibodies/Guinea pig Anti-Angiotensin-(1-7) Mas Receptor Antibody/50 µl/AGP-099-50 µl,Discovery,,Discovery Antibodies,discoveryantibodies,Discovery,Discovery,+,,Array.Array.Array蚂蚁淘厂家直采.
主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Discovery Antibodies/Guinea pig Anti-Angiotensin-(1-7) Mas Receptor Antibody/50 µl/AGP-099-50 µl
产品编号:AGP-099-50µl
市  场 价:¥7340.00
场      地:美国(厂家直采)
产品分类: 抗体类>二抗>抗豚鼠>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$367.00
品      牌: Discovery
公      司:Discovery Antibodies
公司分类:
Discovery Antibodies/Guinea pig Anti-Angiotensin-(1-7) Mas Receptor Antibody/50 µl/AGP-099-50 µl
商品介绍
Cat #: AGP-099
Alternative Name Proto-oncogene Mas, MAS1
  • Lyophilized Powder
  • Antigen Incl.
  • Type: Polyclonal
    Host: Guinea Pig
    Reactivity: h, m, r
      • Peptide (C)KIRKNTWASHSSK, corresponding to amino acid residues 212-224 of the rat Angiotensin-(1-7) Mas receptor (Accession P12526). 3rd intracellular loop.
        Guinea pig Anti-Angiotensin-(1-7) Mas Receptor Antibody
    Accession (Uniprot) Number P12526
    Gene ID 25153
    Peptide confirmation Confirmed by amino acid analysis and mass spectrometry.
    Homology Mouse, human – identical.
    RRID AB_2756621.
    Purity Affinity purified on immobilized antigen.
    Form Lyophilized powder. Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.
    Isotype Guinea pig total IgG.
    Storage before reconstitution The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
    Reconstitution 25 µl, 50 μl or 0.2 ml double distilled water (DDW), depending on the sample size.
    Antibody concentration after reconstitution 0.8 mg/ml.
    Storage after reconstitution The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
    Negative control antigen storage before reconstitution Lyophilized powder can be stored intact at room temperature for 2 weeks. For longer periods, it should be stored at -20°C.
    Negative control antigen reconstitution 100 µl double distilled water (DDW).
    Negative control antigen storage after reconstitution -20°C.
    Preadsorption Control 1 µg peptide per 1 µg antibody.
    Standard quality control of each lot Western blot analysis.
    Applications: wb
    May also work in: ic*, ifc*, ih*, ip*
      • Guinea pig Anti-Angiotensin-(1-7) Mas Receptor Antibody
        Western blot analysis of rat brain lysate (lanes 1 and 3) and mouse brain membranes (lanes 2 and 4):
        1,2. Guinea pig Anti-Angiotensin-(1-7) Mas Receptor Antibody (#AGP-099), (1:600).
        3,4. Guinea pig Anti-Angiotensin-(1-7) Mas Receptor Antibody, preincubated with the negative control antigen.
    References
    • 1. Santos, R.A. et al. (2003) Proc. Natl. Acad. Sci. U.S.A. 100, 8258.
    • 2. Alenina, N. et al. (2008) Exp. Physiol. 93, 528.
    • 3. Santos, R.A. et al. (2008) Exp. Physiol. 93, 519.
      • The Angiotensin-(1-7) Mas receptor is the recently identified receptor of the biologically active heptapeptide angiotensin-(1-7).1
         
        Angiotensin (Ang)-(1-7) is a metabolite of the well known peptide hormone Angiotensin (Ang) II, a key component of the renin-angiotensin system (RAS) that has a central role in cardiovascular homeostasis.
         
        Considerably interest in Ang-(1-7) and its receptor aroused in the last few years since it became apparent that it can counterbalance most of Ang II effects. Thus Ang-(1-7) has vasodilator and hypotensive effects as well as antiarrhythmic and cardioprotective roles.2, 3
         
        The Ang-(1-7) Mas receptor belongs to the 7-transmembrane domain, G protein-coupled receptor (GPCR) superfamily and was originally described as a protooncogene.

        Signaling via the Ang-(1-7) Mas receptor is still poorly elucidated however, evidence indicates that the receptor is coupled to a Gq/11 protein that activates phospholipase C (PLC).2,3
         
        The Ang-(1-7) Mas receptor is expressed in several organs including heart, kidney, blood vessels, testis and brain. Studies with Ang-(1-7) Mas receptor knockout mice have demonstrated the key role of this receptor in cardiovascular regulation as well as in the regulation of learning and memory.2

    Application key:

    CBE- Cell-based ELISA, FC- Flow cytometry, ICC- Immunocytochemistry,IE- Indirect ELISA, IFC- Indirect flow cytometry,
    IF- Immunofluorescence, IHC- Immunohistochemistry, IP- Immunoprecipitation,LCI- Live cell imaging, N- Neutralization, WB- Western blot

    Species reactivity key:

    H- Human, M- Mouse, R- Rat
    receivea 25 µl free trial sample!
    Last update: 14/08/2019

    Alomone Labs is pleased to offer a highly specific antibody directed against an epitope of the rat protein. Guinea pig Anti-Angiotensin-(1-7) Mas Receptor Antibody (#AGP-099) raised in guinea pig can be used in western blot analysis. It has been designed to recognize Ang-(1-7) Mas receptor from rat, mouse and human samples. The antigen used to immunize guinea pigs is the same as Anti-Angiotensin-(1-7) Mas Receptor Antibody (#AAR-013) raised in rabbit. Our line of guinea pig antibodies enables more flexibility with our products such as immuno-colocalization studies, immunoprecipitation, etc.

    For research purposes only, not for human use
    品牌介绍

    Discoveryantibodies


    CRB是世界上第二大肽公司,也是抗体研究市场的先驱,它现在正在探索抗体的旗帜下建立一批新验证的目标抗体。


    CRB, the 2nd oldest peptide company in the world and forerunner in the antibody research market is now building a collection of newly validated target antibodies under the banner of Discovery® Antibodies.


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