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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Discovery Antibodies/trans-ACBD/10 mg/A-280-10 mg
产品编号:A-280-10mg
市  场 价:¥2740.00
场      地:美国(厂家直采)
产品分类: 抗体类>二抗>抗生物素>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$137.00
品      牌: Discovery
公      司:Discovery Antibodies
公司分类:
Discovery Antibodies/trans-ACBD/10 mg/A-280-10 mg
商品介绍
Cat#:A-280
AlternativeName1-Aminocyclobutane-1,3-dicarboxylicacid
  • LyophilizedPowder
  • BioassayTested
  • SourceSynthetic
    MW:159.14
    Purity:>95%
    FormLyophilizedpowder.
    Effectiveconcentration0.1-20µM.
      • trans-ACBD
    Chemicalname1-aminocyclobutane-1,3-dicarboxylicacid.
    MolecularformulaC6H9NO4.
    CASNo.:117488-23-0.
    Activitytrans-ACBDisanNMDAreceptoragoNIST1,2.
      • Allan,R.D. etal. (1990) J.Med.Chem. 33, 2905.
      • Erreger,K. etal. (2007) Mol.Pharmacol. 72, 907.
    ShippingandstorageShippedatroomtemperature.Productassuppliedcanbestoredintactatroomtemperatureforseveralweeks.Forlongerperiods,itshouldbestoredat-20°C.
    Solubility500mMinH2O.Centrifugeallproductpreparationsbeforeuse(10,000xgfor1min).
    StorageofsolutionsUptofourweeksat4°Corthreemonthsat-20°C.
      • trans-ACBD
        AlomoneLabstrans-ACBDactivatesNMDAreceptors(NR1+NR2A)expressedinXenopusoocytes. 
        TimecourseofNMDAreceptorcurrentactivationby2and10μM trans-ACBD (#A-280)(at-80mV).Forcomparison,asolutioncontaining10µMglutamateand10µMglycinewasappliedfor2.5minresultingincurrentsofcomparableamplitude(asindicated).Amplitudechangeasaresultoftheapplicationofraisingconcentrationsoftrans-ACBD(perfusiondurationindicatedbythehorizontalbar,concentrationasindicated).
    References-Scientificbackground
    • 1.Fletcher,E.J. etal. (1991) Neurosci.Lett. 121, 133.
    • 2.Allan,R.D. etal. (1990) J.Med.Chem. 33, 2905.
    • 3.Talukder, I. etal.(2010) J.Neurosci. 30, 11792.
      • trans-ACBDisapotent,competitiveandselectiveactivatorofglutamateuptake.ThecompoundactsasanNMDA(N-methyl-D-aspartate)receptoragonist.TheACBDstructureincludestwoisomers:cis-1-aminocyclobutane-1,3-dicarboxylicacidandtrans-1-aminocyclobutane-1,3-dicarboxylicacid.Severalstudieshaveshownthatthetransisomerismorepotentthanthecisisomer.Thetransisomerwasalsoshowntobe20timesmoreactivethanNMDA1,2,themajorexcitatoryneurotransmitterinthemammaliancentralnervoussystem(CNS).

        SeveralstudiessuggestthatmodificationsandchangesofglutamateuptakecouldplayaroleinprocessesunderlyingsynapticplasticityintheCNS2.

        NMDAreceptorsareionchannelsgatedbyglutamate.Glutamate-mediatedsignalingisimportantforbasicneuron-neuronsignalingandneuronalprocessessuchaslearning,memoryandpainperception3.

    TargetNMDAreceptors
    receivea5mgfreetrialsample!
    Lastupdate:24/09/2019

    trans-ACBD(#A-280) isahighlypure,synthetic,andbiologicallyactivecompound.

    Forresearchpurposesonly,notforhumanuse
    品牌介绍

    Discoveryantibodies


    CRB是世界上第二大肽公司,也是抗体研究市场的先驱,它现在正在探索抗体的旗帜下建立一批新验证的目标抗体。


    CRB, the 2nd oldest peptide company in the world and forerunner in the antibody research market is now building a collection of newly validated target antibodies under the banner of Discovery® Antibodies.


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